$575B
Estimated employer productivity costs in 2019.
Includes absence, disability and reduced work output. This is a productivity-cost estimate, not lost revenue.
Integrated Benefits Institute · 2019 estimateFOR FAMILY OFFICES & PRIVATE CLIENTS
Your wealth has a strategy.
Your health deserves one, too.
A personalized, physician-led advisory for family office principals, entrepreneurs and families with significant responsibilities. Bring greater clarity to the health decisions that shape your ability to lead, enjoy your life and be present for the people who matter.
PERSONAL. PHYSICIAN-LED. PURPOSEFUL.


THE SINICROPI PERSPECTIVE
For the life you have built. And everything you still want to do.
Your ability to think clearly, move freely, recover well and remain engaged underpins everything else.
You may have thoughtful plans for your investments, your business and your family’s future. Health deserves an equally considered approach: a clear view of your priorities, an informed understanding of your options and a plan that evolves with your life.
Sinicropi Longevity Advisory brings those conversations together, placing the person behind the balance sheet at the center of the strategy.
Health is not simply another asset.
It is the capacity to participate in everything you value.

COGNITIVE HEALTH · A FIRST PRINCIPLE
Clear thinking, judgment, independence and connection belong at the center of a longevity strategy. Explore our approach to individualized assessment, appropriate advanced testing and a disciplined evaluation of emerging options.
Explore cognitive health & preservationLost time. Reduced capacity. Interrupted leadership. Population research shows why health belongs in a serious conversation about continuity.
$575B
Includes absence, disability and reduced work output. This is a productivity-cost estimate, not lost revenue.
Integrated Benefits Institute · 2019 estimate17.3M
A national model illustrates how one condition can affect the time available for work.
American Diabetes Association · 2022 data$90–118B
Absenteeism and reduced performance at work, modeled from a national worker survey.
Asfaw et al. · Published 2026, using 2021 dataThese population-level estimates provide context, not a prediction of your revenue, personal risk or savings from this advisory. They overlap, cover different years and must not be added together.
Sources & perspectiveFor a founder or family principal, health also belongs in the conversation about leadership continuity. Research on CEO hospitalization has found effects on firm profitability and investment. The relevance is a reason to plan thoughtfully, rather than a forecast of what any one person will lose.
Bennedsen, Pérez-González & Wolfenzon · Journal of Finance, 2020CLARITY. CONNECTION. CONTINUITY.
Your goals, your health information and the right clinical perspectives belong in one coherent conversation.
Explore your five-pillar frameworkSinicropi Longevity Advisory helps you make sense of health information, establish priorities and navigate the next steps with your care team. Work with us privately, or explore a coordinated engagement for the principals and key leaders your organization supports.
01 / FOR INDIVIDUALS & FAMILIES
For founders, executives and private individuals who want a considered plan for their health, cognitive abilities and capacity to live fully. The starting point is your life, not a preselected menu of tests.
A personalized blueprint, a prioritized next-step plan and an agreed approach to coordination and review.
02 / FOR FAMILY OFFICES & COMPANIES
For family offices supporting principals and families, and companies exploring advisory support for founders or key executives. Begin with a defined group and a clear scope of responsibility.
Who is included, the individual advisory scope, coordination responsibilities, consent boundaries and the rhythm of review.
The scope, fees and review frequency are confirmed before enrollment. Tests, treatments and specialist services are included only when expressly agreed and clinically appropriate. Organizational sponsorship does not grant access to an individual’s health information. Any sharing must follow that person’s authorization and applicable privacy requirements. Advisory guidance complements care from the clinicians responsible for diagnosis and treatment.
Bring your goals, existing health information and relevant clinical perspectives into one considered conversation.
CONTEXT & ASSESSMENTDevelop a personalized blueprint that organizes priorities, questions for your care team and an actionable direction.
YOUR PERSONAL BLUEPRINTNavigate appropriate diagnostic and specialist options in coordination with the clinicians responsible for your care.
COORDINATION & NAVIGATIONRevisit progress and priorities over time, with the scope and rhythm of review established for your engagement.
REVIEW & CONTINUITYEach engagement is scoped individually. Clinical services, testing, specialist involvement, location, fees and review cadence are confirmed before enrollment; no universal testing or treatment package is implied.

A CONVERSATION ABOUT YOUR LIFE
The most important questions are personal. What do you want the next chapter of your life to look like? What responsibilities depend on you? Where would greater clarity make a difference?
We begin by listening. Then we bring clinical perspective and a structured framework to the choices ahead, in coordination with your care team.
Begin your private conversationA signature framework that connects the foundations of health with the life you want to lead. Explore the original collection, then the perspective behind each pillar.

The capacity you build on

A considered view of performance

The ability to restore and adapt

An informed view of risk

Insight translated into a plan
The original five-pillar collection. The artwork retains the Sinicropi CMO Advisory signature. It illustrates areas for consideration, not a list of services automatically included in an engagement.
Testing and treatment depend on individual clinical need and appropriately licensed treating clinicians. The framework does not guarantee disease detection, prevention or outcomes, continuous monitoring, or legal or financial fiduciary services.
These are the original artwork labels, reproduced for accessibility. They express framework concepts, not guaranteed benefits or automatically included services. Clinical scope is individualized; no financial or legal fiduciary service is implied.
Metabolic & Structural Integrity. “The bedrock. Without it, no optimization will hold.” Cardiovascular risk; insulin & glucose control; inflammation & oxidative stress; cardiorespiratory function; body composition; structural & functional integrity.
Hormonal & Cellular Optimization. “The system that generates everything you produce.” Sex hormone optimization; thyroid & adrenal function; epigenetic biological age; glycome age; mitochondrial & cellular health; growth & repair signals.
Sleep, Neurological & Gut Restoration. “Recovery is where adaptation happens.” Sleep architecture & HRV; gut microbiome & barrier; neurological & cognitive markers; continuous glucose monitoring; stress axis & cortisol rhythm.
Catastrophic Risk Mitigation. “Protection against the event that ends everything.” Cardiovascular imaging; cancer detection; neurodegeneration risk; toxic burden; the fiduciary shield. These aspirational labels do not guarantee that disease can be detected or prevented.
Strategy, Execution & Oversight. “Data without execution is just expensive anxiety.” Clinical synthesis; the intervention roadmap; therapeutic protocols; continuous monitoring; specialist coordination; concierge execution. Monitoring, services and access are subject to the separately agreed engagement scope.
All five plaques carry the Sinicropi CMO Advisory signature.
The capacity you build on
+Metabolic health, cardiovascular risk, strength, mobility and physical function form the baseline for a considered health strategy.
METABOLIC & STRUCTURAL HEALTHThe biology behind performance
+Consider hormonal and cellular health in context, with careful interpretation of relevant findings and attention to what is actionable.
HORMONAL & CELLULAR PERSPECTIVEThe ability to restore and adapt
+Explore sleep, stress, recovery, cognitive well-being and gut health as part of the larger picture of everyday function.
SLEEP, RECOVERY & RESILIENCEA more informed view of risk
+Review prevention and screening priorities with qualified clinicians. The aim is informed planning, not a promise that all disease can be predicted or prevented.
PREVENTION & RISK AWARENESSTurn insight into a living plan
+Synthesize the findings into priorities, a personalized roadmap, coordination and a thoughtful approach to reassessment.
STRATEGY, EXECUTION & OVERSIGHTTHE JUDGMENT BETWEEN THE DATA POINTS
A way to organize a personalized strategy. It is not a validated clinical score or a universal testing protocol.
Research can help identify priorities. An advisory conversation can organize the questions, trade-offs and next steps to discuss with your clinicians.
These studies evaluated specific interventions, not Sinicropi Longevity Advisory. They do not establish that this service prevents illness, extends life or delivers a financial return.
01 / DIABETES PREVENTION PROGRAM · 2002
In a randomized trial of 3,234 adults with elevated glucose, an intensive lifestyle program reduced diabetes incidence compared with placebo plus standard advice.
Estimated cumulative incidence (%) · zero-based scale, 0–35%
Selected high-risk adults, not a general healthy population. The program targeted at least 7% weight loss and 150 minutes of weekly activity with individualized support. Mean follow-up was 2.8 years; the trial ended early. Musculoskeletal symptoms were more frequent with lifestyle intervention; gastrointestinal symptoms with metformin.
Read the original randomized trial02 / SPRINT · FINAL REPORT, 2021
Among 9,361 adults aged 50 or older with elevated blood pressure and cardiovascular risk, more intensive treatment reduced cardiovascular events but increased some serious adverse events.
Events per 100 person-years · both scales start at zero and end at 3 · not cumulative percentages
Primary cardiovascular composite
Serious acute kidney injury or renal failure
Median follow-up 3.33 years; intervention ended early. People with diabetes or prior stroke were excluded. The cardiovascular outcome combined heart attack, other acute coronary syndrome, stroke, acute heart failure and cardiovascular death. Hypotension and electrolyte abnormalities also increased; the overall serious-adverse-event difference was not statistically significant. Trial targets are not individualized treatment advice.
Read the final trial reportTHE STANDARD WE HOLD
A large randomized workplace-wellness trial found improvements in some reported behaviors, but no significant clinical, spending or employment benefits after 18 months. It did not test this advisory. We do not promise guaranteed health outcomes or financial returns.
JAMA, 2019 · 160 worksites, 32,974 employeesFROM PUBLISHED EVIDENCE TO YOUR OWN PRIORITIES
What did the study actually measure?
Does that population resemble your circumstances?
Discuss benefits, harms and alternatives with your clinicians.
Choose an appropriate action and a plan for review.
A clear way to bring personal health priorities into the broader conversation about family continuity, responsibility and the years ahead.
A health strategy that recognizes demanding schedules, competing priorities and the importance of sustained personal engagement.
A more organized conversation about your health information, your options and the decisions that deserve attention.
The economics of continuity
Explore how time away, reduced capacity and continuity arrangements could affect personal income or an executive-dependent organization. Change the assumptions to frame a more informed conversation.
Original Sinicropi scenario design, informed by published work-capacity research. These financial calculations are illustrative and have not been clinically or actuarially validated.
Choose simple presets to explore a scenario. Menu choices are illustrative assumptions, not recommended or scientifically validated values; each selection uses the exact amount shown.
Use a hypothetical sickness or disability-related interruption, not an assumed likelihood. Enter your annual income, then choose scenario assumptions from the menus or load an illustrative example.
Illustrative scenario estimate · USD
Complete the highlighted assumptions to see your scenario.
Modeled income exposure after offsets
—
One hypothetical episode within a 12-month frame. Assumes earned income scales with available work capacity.
Offsets exceed modeled income exposure. Excess offsets are not applied to expenses.
Explore the capacity tied to one key executive and the portion restored by your continuity arrangements. No illness or disability probability is estimated.
Illustrative scenario estimate · USD
Complete the highlighted assumptions to see your scenario.
Uncovered capacity-value exposure
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A time-based value proxy, not predicted lost revenue or accounting loss.
Capacity-value exposure and continuity spending are shown separately. Adding them may double count costs.
Choose an annual value to estimate monetary exposure, or use uncovered days and continuity spending alone.
Calculations run in your browser. The calculator does not send entries to the advisory team or save them, and the conversation link does not include your assumptions.
An original Sinicropi planning framework. This scenario design is inspired by published absenteeism and presenteeism concepts in the Work Productivity and Activity Impairment (WPAI) and WHO Health and Work Performance Questionnaire (HPQ) literature. Those instruments have published validation evidence in specific settings. These original financial scenarios are not those questionnaires, do not generate their scores and have not been clinically or actuarially validated. No questionnaire wording is reproduced.
Time basis. Use one episode within a 12-month period. Equivalent workdays lost = fully absent days + reduced-capacity days × (1 − remaining capacity / 100). Absent and reduced-capacity days are distinct and together cannot exceed annual scheduled workdays. The default of 240 annual workdays and all menu options are scenario choices, not population benchmarks or scientifically validated presets. Each menu amount is an exact assumption, not a range; compare nearby choices if your situation falls between them.
Personal income. Income exposure before offsets = annual work-dependent earned income ÷ annual workdays × equivalent workdays lost. Income exposure after offsets = the greater of zero or exposure before offsets minus income preserved/replaced for that loss. Exposure + added expenses = exposure after offsets + additional net expenses. Offsets are capped at income exposure; any excess is not applied to expenses. Continued salary, benefit waiting periods, caps, eligibility, taxes and duration can materially change actual receipts. Confirm these separately; this is not an insurance-benefit calculation.
Business and family office. Uncovered equivalent days = equivalent workdays lost × (1 − restored-output percentage / 100). Capacity-value exposure = attributable annual economic value ÷ annual workdays × uncovered equivalent days. Annual value may use compensation as a capacity proxy or an internally estimated attributable value-added basis. For a profit-oriented estimate, use contribution value after variable costs, not gross revenue. Compensation is not revenue; neither basis establishes causality. Continuity cash spending is reported separately to avoid an unsupported total or double counting. If a defensible monetary value is unavailable, choose “Skip monetary estimate” and review uncovered days instead.
Limits. Linear time-to-value conversion is an explicit simplifying assumption. Work made up later, dependencies, timing, salaried pay and decision bottlenecks may produce different real-world effects. No estimates of disability probability, future health, enterprise valuation, investment returns or program ROI are produced. No claim is made that advisory services will prevent the scenario or reduce its cost. Dollar amounts are USD, rounded for display only.
Published foundations: Reilly et al. (1993), WPAI validation; Zhang et al. (2010), WPAI-GH measurement and scoring; Kessler et al. (2003), WHO-HPQ; CDC (2016), time-based absenteeism costing. Research supports the measurement concepts, not the predictive accuracy of this calculator.
STEFANO M. SINICROPI, MD, FAAOSDr. Stefano Sinicropi works at the intersection of clinical medicine, health innovation and human potential.
A board-certified orthopedic spine surgeon and President & CEO of Midwest Spine & Brain Institute, he is the founder of HyperCharge Health and the 24th President of the Society for Brain Mapping and Therapeutics.
His approach connects the interpretation of health information with the questions that matter in daily life: how we think, move, recover and remain engaged.
There is no one-size-fits-all path. The initial conversation is about your priorities, the advisory’s fit and what an appropriate engagement could involve.
Share what brought you here, the responsibilities you carry and the questions you want to address.
Discuss the appropriate assessment, coordination, review structure and fees before making a commitment.
Develop a personalized direction with clear priorities and an agreed approach to ongoing review.
SELECTED PERSPECTIVES · STEFANO M. SINICROPI, MD
Four selected essays on health as family capital, leadership continuity, better decisions and disciplined longevity due diligence.
Wealth creates options. Biological reserve helps determine which of those options you can continue to use. A practical framework for protecting the physical, cognitive, and recovery capacity that supports a demanding life.
Read the full essay LEADERSHIP & CONTINUITYWhat would become fragile if a principal had less usable capacity for 90 days? A privacy-conscious approach to protecting leadership continuity, decision rights, and family-enterprise resilience.
Read the full essay DECISION-GRADE LONGEVITYAdvanced testing earns its place when it changes a meaningful decision. Five questions help turn executive-health data into clearer choices, appropriate prevention, and outcomes that matter.
Read the full essay LONGEVITY DUE DILIGENCEApply the discipline of investment due diligence to longevity. An Evidence Room makes the intervention, supporting research, uncertainty, alternatives, and reassessment rules visible before a commitment.
Read the full essaySelected from Dr. Sinicropi’s existing Substack drafts and adapted for this private website review. These are not represented as published Substack posts.
The advisory is intended to bring perspective, organization and coordination to your health strategy. It does not automatically replace your existing physicians. Any clinical care relationship and responsibilities must be agreed separately with the appropriate licensed providers.
No. The five pillars organize the conversation; they are not a universal prescription. Testing and treatment decisions require clinical judgment, evidence, individual suitability and an agreed scope of care.
Scope, duration, access, review cadence and fees are discussed individually before enrollment. Separate testing, clinical, travel or specialist costs, if applicable, should be clarified as part of that discussion.
Yes. A principal, family office representative or authorized assistant can request an introductory conversation. Please share only business contact information and broad interests through this form; health records and sensitive personal information should not be included.
Tell us a little about your interests. The first step is a conversation about fit, priorities and possibilities.